RNA-SEQ ANALYSIS OF GENE EXPRESSION PROFILES IN ISOLATED STRIA VASCULARIS FROM WILD-TYPE AND ALPORT MICE REVEALS KEY PATHWAYS UNDERLING ALPORT STRIAL PATHOGENESIS.

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Previous work demonstrates that the hearing loss in Alport mice is caused by defects in the stria vascularis.As the animals age, progressive thickening of strial capillary basement membranes (SCBMs) occurs associated with elevated levels of extracellular matrix expression and hypoxia-related gene and protein expression.These conditions render the a

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Prediction of blasting mean fragment size using support vector regression combined with five optimization algorithms

The main purpose of blasting operation is to produce desired and optimum mean size rock fragments.Smaller or fine fragments cause the loss of ore during loading and transportation, whereas large or coarser fragments need to be further processed, which enhances production cost.Therefore, accurate prediction of rock fragmentation is crucial in blasti

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